Kangsheng Gu, Di Wu, Jingjing Wu
Tumori. 2014 Jan-Feb;100(1):21-5. doi: 10.1700/1430.15810.
To analyze the clinical characteristics, therapeutic short-term efficacy, long-term survival and influencing factors in 68 cases of peripheral T-cell lymphoma unspecified.
Sixty-eight cases of peripheral T-cell lymphoma unspecified were retrospectively studied. The effect of different treatments on survival of patients was analyzed by the Kaplan-Meier method. Using single factor analysis and the Cox proportional hazards regression model, the effect of the various clinical factors on the survival of patients was evaluated.
The complete remission rate of 68 cases of peripheral T-cell lymphoma unspecified according to treatment was 28%. The 5-year overall survival rate was 25.63%. Chemotherapy alone and chemotherapy combined with radiotherapy gave overall survival rates of 19.4% and 37.1%, respectively. Chemotherapy combined with radiotherapy gave a long-term survival rate significantly superior to that of chemotherapy alone (P <0.05).
Patients with peripheral T-cell lymphoma unspecified treated by the CHOP chemotherapy regimen had a high response rate but a low long-term survival rate. A complete remission with initial treatment and chemotherapy combined with radiotherapy can improve patient survival. The performance score before treatment, therapeutic effect, and bone marrow involvement are independent factors that affect survival.
分析68例非特指外周T细胞淋巴瘤的临床特征、治疗短期疗效、长期生存情况及影响因素。
回顾性研究68例非特指外周T细胞淋巴瘤患者。采用Kaplan-Meier法分析不同治疗方法对患者生存的影响。运用单因素分析和Cox比例风险回归模型评估各临床因素对患者生存的影响。
68例非特指外周T细胞淋巴瘤患者经治疗后的完全缓解率为28%。5年总生存率为25.63%。单纯化疗和化疗联合放疗的总生存率分别为19.4%和37.1%。化疗联合放疗的长期生存率显著优于单纯化疗（P<0.05）。
采用CHOP化疗方案治疗的非特指外周T细胞淋巴瘤患者缓解率高但长期生存率低。初始治疗达到完全缓解且化疗联合放疗可提高患者生存率。治疗前的体能状态评分、治疗效果及骨髓受累情况是影响生存的独立因素。
