Su Qiang, Sun Yu-Ping, Liu Ye-Hui, Li Zhe, Yang Hong-Yan, Sun Zhi-Gang, Cao Bang-Wei, Jia Ji-Hui
Tumori. 2014 Jan-Feb;100(1):69-74. doi: 10.1700/1430.15818.
The human life expectancy and the incidence of lung cancer have increased dramatically in recent years. As a result, there is a high demand for the management of older patients with advanced non-small cell lung cancer (NSCLC) in clinical practice. The purpose of this study is to evaluate the prognostic factors in ≥65-year-old patients with advanced NSCLC in China.
This study involved a retrospective review of 78 ≥65-year-old patients with a diagnosis of NSCLC and at an advanced stage of disease, defined as stage IIIB or IV. All patients were followed up for a 3-year interval to determine the survival rates. Clinical data including gender, smoking history, comorbidities, performance status (PS), histological differentiation, disease stage, treatment and overall survival were recorded. The log-rank test was used to calculate survival rates. Multivariate Cox regression analysis was performed to determine independent prognostic factors.
The 1-year, 2-year and 3-year survival rates of the 78 patients were 44.9%, 23.1% and 9.0%, respectively. In univariate analysis by the log-rank test, the 3-year survival rate was significantly associated with PS (P <0.01), disease stage (P <0.01) and chemotherapy treatment (P <0.01). The results of multivariate Cox regression analysis confirmed that PS and disease stage were independent prognostic factors.
The 3-year survival rate in ≥65-year-old patients with advanced NSCLC was significantly associated with PS, disease stage and chemotherapy. PS and disease stage were independent prognostic factors. Older patients with advanced NSCLC in China might benefit from chemotherapy.
近年来，人类预期寿命和肺癌发病率显著上升。因此，临床实践中对老年晚期非小细胞肺癌（NSCLC）患者的管理需求很高。本研究旨在评估中国≥65岁晚期NSCLC患者的预后因素。
本研究对78例≥65岁、诊断为NSCLC且处于疾病晚期（定义为IIIB期或IV期）的患者进行了回顾性分析。所有患者随访3年以确定生存率。记录临床数据，包括性别、吸烟史、合并症、体能状态（PS）、组织学分化、疾病分期、治疗情况和总生存期。采用对数秩检验计算生存率。进行多因素Cox回归分析以确定独立预后因素。
78例患者的1年、2年和3年生存率分别为44.9%、23.1%和9.0%。在对数秩检验的单因素分析中，3年生存率与PS（P<0.01）、疾病分期（P<0.01）和化疗治疗（P<0.01）显著相关。多因素Cox回归分析结果证实，PS和疾病分期是独立预后因素。
≥65岁晚期NSCLC患者的3年生存率与PS、疾病分期和化疗显著相关。PS和疾病分期是独立预后因素。中国老年晚期NSCLC患者可能从化疗中获益。
