Endogenous estrogen exacerbates UV-induced inflammation and photoaging in mice.

作者信息

Yoon Hyun-Sun, Shin Chang-Yup, Kim Yeon Kyung, Lee Se-Rah, Chung Jin Ho

机构信息

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea; Department of Dermatology, Seoul National University Boramae Hospital, Seoul, Korea.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea; Institute of Human-Environment Interface Biology, Seoul National University, Seoul, Korea.

出版信息

J Invest Dermatol. 2014 Aug;134(8):2290-2293. doi: 10.1038/jid.2014.160. Epub 2014 Mar 27.

DOI:10.1038/jid.2014.160

PMID:24675752

Abstract

摘要

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Endogenous estrogen exacerbates UV-induced inflammation and photoaging in mice.

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Estradiol inhibits ongoing autoimmune neuroinflammation and NFkappaB-dependent CCL2 expression in reactive astrocytes.雌二醇抑制活性星形胶质细胞中持续的自身免疫性神经炎症和 NFkappaB 依赖性 CCL2 表达。

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Ann N Y Acad Sci. 2009 Apr;1160:322-8. doi: 10.1111/j.1749-6632.2009.03830.x.

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