外周血端粒长度在子宫内膜异位症患者中长于对照组。
Peripheral blood telomere content is greater in patients with endometriosis than in controls.
机构信息
Obstetrics and Gynecology Department of New York University School of Medicine, New York, NY, USA Endometriosis Department of the Medical School of Sao Paulo University, Sao Paulo, SP, Brazil
Obstetrics and Gynecology Department of New York University School of Medicine, New York, NY, USA.
出版信息
Reprod Sci. 2014 Dec;21(12):1465-71. doi: 10.1177/1933719114527353. Epub 2014 Mar 27.
UNLABELLED
The etiology of endometriosis remains poorly understood but circulating stem cells may contribute. Telomeres shorten with cell divisions and age. Stem cells attempt to compensate for telomere attrition through the action of telomerase. Since circulating stem cells may contribute to endometriosis, we compared telomere content in lymphocytes of patients with and without endometriosis.
METHODS
Observational study comparing peripheral lymphocytes telomere content, measured by quantitative polymerase chain reaction, in patients with (n = 86) and without endometriosis (n = 21).
FINDINGS
Patients with endometriosis had longer telomeres than that of matched, endometriosis-free controls (telomere to single copy gene ratio [T/S ratio] of 1.62 vs 1.34, respectively, P = .00002). Patients with endometriosis were 8.1-fold more likely to have long telomeres. (odds ratio = 8.1, 95% confidence interval: 1.28-51.57, P = .0264).
INTERPRETATION
Longer telomeres could be consistent with a stem cell origin of endometriosis.
未注明
子宫内膜异位症的病因仍不清楚，但循环干细胞可能有贡献。端粒随细胞分裂和年龄而缩短。干细胞试图通过端粒酶的作用来补偿端粒损耗。由于循环干细胞可能有助于子宫内膜异位症，我们比较了子宫内膜异位症患者（n=86）和无子宫内膜异位症患者（n=21）外周血淋巴细胞中端粒的含量。
方法
通过定量聚合酶链反应比较子宫内膜异位症患者和无子宫内膜异位症患者外周血淋巴细胞中端粒的含量，用端粒与单拷贝基因的比值（T/S 比值）表示。
发现
子宫内膜异位症患者的端粒比匹配的无子宫内膜异位症对照组长（T/S 比值分别为 1.62 和 1.34，P=0.00002）。子宫内膜异位症患者具有长端粒的可能性增加了 8.1 倍（比值比=8.1，95%置信区间：1.28-51.57，P=0.0264）。
解释
较长的端粒可能与子宫内膜异位症的干细胞起源一致。
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