[重症监护病房中药物与肠内营养相互作用的患病率及临床意义]
[Prevalence and clinical significance of interactions drug-enteral nutrition in Intensive Care Units].
作者信息
Reis Adriano Max Moreira, de Carvalho Rhanna Emanuela Fontenele Lima, de Faria Leila Marcia Pereira, de Oliveira Regina Célia, Zago Karine Santana de Azevedo, Cavelagna Milena Ferreira, Silva Adriano Gomes, Neto Manoel Luis, Cassiani Silvia Helena de Bortoli
机构信息
Departamento de Produtos Farmaceuticos, Faculdade de Farmacia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Departamento de Enfermagem, Universidade Estadual do Ceara, Fortaleza, CE, Brasil.
出版信息
Rev Bras Enferm. 2014 Jan-Feb;67(1):85-90. doi: 10.5935/0034-7167.20140011.
This is a multicenter, cross-sectional retrospective study, which aimed to determine the prevalence of interactions drug-enteral nutrition (EN) in Intensive Care Units (ICU) of seven teaching hospitals in Brazil, and to analyze the clinical significance of them. Information on medications and EN administered with 24 hours and 120 hours of hospitalization were collected. For identification of drug-EN interaction was employed software Drug Reax®. It was investigated 1.124 records. Of these, 320 patients, with 24 hours of hospitalization, were on EN, and 20 (6.3%) had drug-EN interaction. Of the 504 patients with 120 hours of hospitalization, 39 (7.7%) had drug-EN interaction. The most frequent drug-EN interactions of clinical significance were phenytoin-EN, warfarin-EN and levothyroxine-EN. Drug-EN interactions may interfere with the quality and cost effectiveness of care in ICU, so it is essential that the health team has knowledge about them.
这是一项多中心横断面回顾性研究，旨在确定巴西七家教学医院重症监护病房（ICU）中药物与肠内营养（EN）相互作用的发生率，并分析其临床意义。收集了住院24小时和120小时内使用的药物和EN的信息。使用Drug Reax®软件识别药物与EN的相互作用。共调查了1124份记录。其中，320例住院24小时的患者接受了EN，20例（6.3%）存在药物与EN的相互作用。在504例住院120小时的患者中，39例（7.7%）存在药物与EN的相互作用。具有临床意义的最常见药物与EN相互作用为苯妥英-EN、华法林-EN和左甲状腺素-EN。药物与EN的相互作用可能会干扰ICU护理的质量和成本效益，因此医疗团队了解这些相互作用至关重要。
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