Cuevas L E, Hart C A, Molyneux M, Mughogho G H
School of Tropical Medicine, Liverpool, U.K.
Ann Trop Paediatr. 1988 Dec;8(4):230-3. doi: 10.1080/02724936.1988.11748577.
We have studied prospectively the C-reactive protein values in the cerebrospinal fluid of 54 patients with bacterial meningitis, tuberculous meningitis, and severe malarial infection and convulsions without infections of the central nervous system. CSF CRP above 1 mg/l was observed in 23 out of 28 patients with bacterial meningitis (sensitivity of 82%). The specificity was 73% at the 1 mg/l level. Five out of 19 patients with severe malarial infection had CSF CRP levels above 1 mg/l. Two patients with TB meningitis were also studied. Both of them had CSF CRP above 1 mg/l. Five patients with febrile convulsions or sepsis without meningitis had CSF CRP below 1 mg/l. It is concluded that CSF CRP would not be used as a useful discriminatory test in areas where malaria and TB meningitis are common.
我们前瞻性地研究了54例患有细菌性脑膜炎、结核性脑膜炎、严重疟疾感染以及无中枢神经系统感染的惊厥患者脑脊液中的C反应蛋白值。在28例细菌性脑膜炎患者中，有23例脑脊液C反应蛋白高于1mg/l（敏感性为82%）。在1mg/l水平时，特异性为73%。19例严重疟疾感染患者中有5例脑脊液C反应蛋白水平高于1mg/l。还研究了2例结核性脑膜炎患者，他们的脑脊液C反应蛋白均高于1mg/l。5例热性惊厥或无脑膜炎的败血症患者脑脊液C反应蛋白低于1mg/l。得出的结论是，在疟疾和结核性脑膜炎常见的地区，脑脊液C反应蛋白不能作为一项有用的鉴别检测指标。
