Feenstra A, Kirch D G, Bracha H S, Wyatt R J
Neuropsychiatry Branch, NIMH, Saint Elizabeths Hospital, Washington, D.C.
Biol Psychiatry. 1989 Feb 15;25(4):421-30. doi: 10.1016/0006-3223(89)90195-9.
The evidence that schizophrenia may involve infection by a virus (or viruses) has been indirect. The recent discovery, however, of the human retroviruses--human T-cell lymphoma-leukemia virus-I, and II (HTLV-I, -II) and human immunodeficiency virus (HIV)--now also known to affect the central nervous system (CNS), together with the development of new techniques in retrovirology, have made it possible to investigate more directly the role of this class of viruses as an etiology of schizophrenia. In our first effort to screen for the presence of a T-cell lymphotropic virus in schizophrenia, short-term tissue cultures of peripheral lymphocytes from 17 chronic schizophrenic patients and 10 normal controls were established. The cells were cultured in the presence of T-cell growth factor (TCGF, IL-2), and the culture supernatants were tested for the presence of the retroviral enzyme reverse transcriptase. No T-cell-associated reverse transcriptase activity was detected in cultures from patients or normal controls. Therefore, the data do not provide evidence for a role for T-cell lymphotropic retroviruses as an etiology of schizophrenia.
精神分裂症可能与一种或多种病毒感染有关的证据一直是间接的。然而，最近发现的人类逆转录病毒——人类T细胞淋巴瘤白血病病毒I型和II型（HTLV-I、-II）以及人类免疫缺陷病毒（HIV）——现在也已知会影响中枢神经系统（CNS），再加上逆转录病毒学新技术的发展，使得更直接地研究这类病毒作为精神分裂症病因的作用成为可能。在我们首次筛查精神分裂症患者中是否存在嗜T细胞病毒的研究中，我们建立了17例慢性精神分裂症患者和10例正常对照者外周淋巴细胞的短期组织培养。细胞在T细胞生长因子（TCGF，白细胞介素-2）存在的情况下进行培养，并检测培养上清液中逆转录病毒酶逆转录酶的存在情况。在患者或正常对照者的培养物中均未检测到与T细胞相关的逆转录酶活性。因此，这些数据并未提供嗜T细胞逆转录病毒作为精神分裂症病因的作用的证据。
