Coggiano M A, Alexander R C, Kirch D G, Wyatt R J, Kulaga H
Neuropsychiatry Branch, National Institute of Mental Health, Washington, DC 20032.
Schizophr Res. 1991 Oct;5(3):243-7. doi: 10.1016/0920-9964(91)90082-3.
Retroviral infection has been proposed as an etiologic factor in schizophrenia. In an effort to unmask a latent retrovirus, short term cultures of peripheral lymphocytes from 15 schizophrenic subjects and nine normal controls were exposed to ionizing radiation and co-cultured with indicator cells. Reverse transcriptase activity, a marker of retroviral infection, could not be detected in any of the cultures. Our findings are further evidence against a role for retroviral infection in the etiology of schizophrenia.
逆转录病毒感染已被提出是精神分裂症的一个病因。为了揭示一种潜伏的逆转录病毒，对15名精神分裂症患者和9名正常对照的外周淋巴细胞进行短期培养，使其暴露于电离辐射下，并与指示细胞共培养。在任何培养物中均未检测到逆转录病毒感染的标志物——逆转录酶活性。我们的研究结果进一步证明逆转录病毒感染在精神分裂症病因学中不起作用。
