哌醋甲酯对成人 ADHD 中多巴胺转运体的占有率与冲动性。
Dopamine transporter occupancy by methylphenidate and impulsivity in adult ADHD.
机构信息
Cleo L. Crunelle, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, Belgium; Amsterdam Institute for Addiction Research and Departments of Psychiatry and Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands; Wim van den Brink, MD, PhD, Amsterdam Institute for Addiction Research and Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands; Geert Dom, MD, PhD, Collaborative Antwerp Psychiatric Research Institute (CAPRI), University of Antwerp, and Psychiatric Centre Alexian Brothers, Boechout, Belgium; Jan Booij, MD, PhD, Department of Nuclear Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
出版信息
Br J Psychiatry. 2014 Jun;204(6):486-7. doi: 10.1192/bjp.bp.113.132977. Epub 2014 Mar 27.
Impulsivity is a multidimensional construct, including impulsive decision-making and impulsive action, representing relatively independent neurocircuitries. ADHD is treated with methylphenidate, a drug that binds to dopamine transporters. This study in 24 adult male patients with ADHD shows that dopamine transporter occupancy by methylphenidate in the putamen correlates with improvements in cognitive but not in motor impulsivity.
冲动是一个多维度的结构，包括冲动决策和冲动行为，代表相对独立的神经回路。ADHD 用哌甲酯治疗，一种与多巴胺转运体结合的药物。这项对 24 名成年男性 ADHD 患者的研究表明，纹状体中哌甲酯对多巴胺转运体的占据与认知冲动的改善相关，但与运动冲动无关。
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