Süer Evren, Özcan Cihat, Gökçe Ilker, Gülpınar Ömer, Göğüş Cağatay, Türkölmez Kadir, Baltacı Sümer, Bedük Yaşar
Department of Urology, Ibn-i Sina Hospital, Ankara University, Samanpazarı-Ankara, 06100, Turkey,
Int Urol Nephrol. 2014 Aug;46(8):1521-6. doi: 10.1007/s11255-014-0698-x. Epub 2014 Mar 28.
The purpose of the study was to investigate the effect of ABO blood groups and Rhesus (Rh) factor on prognosis of patients undergoing radical cystectomy.
In this study, total number of 290 patients who underwent radical cystectomy between January 1990 and September 2012 were evaluated retrospectively. Patients were grouped as O and non-O according to ABO antigens; also positive and negative according to Rh factor. Parameters such as age, sex, stage, lymph node involvement and positive surgical margins were investigated. Disease-free and overall survival rates have been compared. Multivariate analysis were performed to determine independent prognostic factors.
A total of 260 (89.7 %) male and 30 (10.3 %) female patients participated in the study. Mean follow-up was 37.7 ± 18.9 months. A total of 180 patients were non-O (62.1 %),while the 110 patients had the blood group O (37.9 %). The number of Rh positive and negative patients were 247 (85.2 %) and 43 (14.8 %), respectively. According to the univariate and multivariate analyses, ABO blood groups and Rh factor did not exhibit any significant impact on overall and disease-specific survival.
ABO blood group and Rh factor were not associated with the prognosis of bladder cancer patients who underwent radical cystectomy. However, prospective studies are needed in larger patient series for further evaluations.
本研究旨在探讨ABO血型和恒河猴（Rh）因子对接受根治性膀胱切除术患者预后的影响。
本研究回顾性评估了1990年1月至2012年9月期间接受根治性膀胱切除术的290例患者。根据ABO抗原将患者分为O型和非O型；根据Rh因子也分为阳性和阴性。研究了年龄、性别、分期、淋巴结受累情况和手术切缘阳性等参数。比较了无病生存率和总生存率。进行多变量分析以确定独立的预后因素。
共有260例（89.7%）男性和30例（10.3%）女性患者参与了本研究。平均随访时间为37.7±18.9个月。共有180例患者为非O型（62.1%），而110例患者为O型血（37.9%）。Rh阳性和阴性患者的数量分别为247例（85.2%）和43例（14.8%）。根据单变量和多变量分析，ABO血型和Rh因子对总生存率和疾病特异性生存率均未表现出任何显著影响。
ABO血型和Rh因子与接受根治性膀胱切除术的膀胱癌患者的预后无关。然而，需要在更大的患者系列中进行前瞻性研究以作进一步评估。
