Liang Juan, Lei Zhiyu, Xu Xiaojun, Zhao Ning, Song Hua, Yang Shilong, Zhao Fenying, Mao Junqing, Liao Chan, Shen Diying, Tang Yongmin
Division of Hematology-Oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Indian J Pediatr. 2014 Sep;81(9):871-5. doi: 10.1007/s12098-014-1361-3. Epub 2014 Mar 28.
To evaluate the role of Th1/Th2 cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ) in differentiating interleukin 11 induced fever with C-reactive protein elevation from early bacterial infection.
A total of 74 patients were enrolled in this retrospective study. Serum Th1/Th2 cytokines were determined using cytometric bead array (CBA) techniques. Whenever the patients had febrile disease or elevated CRP, systemic inflammatory signs, procalcitonin (PCT), blood culture and X-ray examination were done. The patients were assigned into infected and non-infected groups based on the clinical and laboratory findings.
The CRP levels in both the groups were significantly increased, but no statistically significant difference was found (P = 0.574). IL-6 levels of the infected group were significantly elevated with simultaneously elevated IL-10 levels in a proportion of the patients. IL-6 levels of non-infected patients were normal. IL-6 and IL-10 levels of infected patients were significantly higher than those of non-infected patients (P = 0.005, 0.015, respectively).
For the patients treated with recombinant human interleukin 11 (rhIL-11), IL-6 and IL-10 measurements can be a useful adjuvant tool for the differentiation of rhIL-11 induced fever with C-reactive protein elevation from early bacterial infection.
评估Th1/Th2细胞因子（白细胞介素-2、白细胞介素-4、白细胞介素-6、白细胞介素-10、肿瘤坏死因子-α、干扰素-γ）在鉴别白细胞介素11诱导的发热伴C反应蛋白升高与早期细菌感染中的作用。
本回顾性研究共纳入74例患者。采用细胞计数珠阵列（CBA）技术测定血清Th1/Th2细胞因子。每当患者出现发热性疾病或C反应蛋白升高、全身炎症体征时，进行降钙素原（PCT）、血培养及X线检查。根据临床和实验室检查结果将患者分为感染组和非感染组。
两组C反应蛋白水平均显著升高，但差异无统计学意义（P = 0.574）。感染组白细胞介素-6水平显著升高，部分患者白细胞介素-10水平同时升高。非感染患者白细胞介素-6水平正常。感染患者白细胞介素-6和白细胞介素-10水平显著高于非感染患者（分别为P = 0.005、0.015）。
对于接受重组人白细胞介素11（rhIL-11）治疗的患者，检测白细胞介素-6和白细胞介素-10可作为鉴别rhIL-11诱导的发热伴C反应蛋白升高与早期细菌感染的有用辅助手段。
