Cho H J, Basbaum A I
Department of Anatomy, University of California, San Francisco 94143.
Brain Res. 1989 Jan 16;477(1-2):344-9. doi: 10.1016/0006-8993(89)91425-x.
This study provides an anatomical basis for the observation that a unilateral lesion of the spinal dorsolateral funiculus (DLF) can reduce the inhibitory effect of electrical stimulation of the nucleus raphe magnus (NRM) on dorsal horn nociceptive neurons located caudal and contralateral to the lesion. We injected the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L) into the NRM and traced the arborization of single DLF axons in the spinal gray matter. Although the majority of DLF axons arborized in the dorsal horn ipsilaterally, we found some axons which entered the spinal gray matter, traversed the gray matter to the central canal and then abruptly changed direction and coursed to the contralateral superficial dorsal horn. Very few branches were given off en route. These data indicate that some raphe-spinal axons may selectively influence the firing of neurons of the superficial dorsal horn, contralateral to the DLF in which they descend the spinal cord.
脊髓背外侧索（DLF）的单侧损伤可降低电刺激中缝大核（NRM）对位于损伤尾侧和对侧的背角伤害性神经元的抑制作用。我们将顺行示踪剂菜豆白细胞凝集素（PHA-L）注入NRM，并追踪单个DLF轴突在脊髓灰质中的分支情况。尽管大多数DLF轴突在同侧背角分支，但我们发现一些轴突进入脊髓灰质，穿过灰质到达中央管，然后突然改变方向，向对侧浅背角延伸。沿途发出的分支很少。这些数据表明，一些中缝脊髓轴突可能选择性地影响它们在脊髓下行的DLF对侧浅背角神经元的放电。
