Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Cell Biol Int. 2014 Jun;38(6):691-4. doi: 10.1002/cbin.10261. Epub 2014 Feb 24.
Unravelling the autoregulatory network that induces and maintains cancer stem cell state may provide novel effective therapies against breast cancer metastasis. The perivascular niche develops elements that initiate the autoregulatory machine to induce and maintain cancer stem cells, but not EMT, among newly arrived tumour cells. Inhibition of one or more primary key elements that trigger this circuit may result in the prevention or cure of breast cancer metastasis.
阐明诱导和维持癌症干细胞状态的自调节网络，可能为治疗乳腺癌转移提供新的有效疗法。血管周围生态位产生的各种成分启动了自调节机制，从而诱导和维持新进入的肿瘤细胞中的癌症干细胞，但不诱导 EMT。抑制引发该回路的一个或多个主要关键因素，可能会预防或治愈乳腺癌转移。
