伴胸腺样分化的梭形上皮肿瘤：一例报告及文献综述与治疗选择
Spindle epithelial tumor with thymus-like differentiation: A case report and comprehensive review of the literature and treatment options.
作者信息
Recondo Gonzalo, Busaidy Naifa, Erasmus Jeremy, Williams Michelle D, Johnson Faye M
机构信息
Department of Internal Medicine, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, Buenos Aires, Argentina.
出版信息
Head Neck. 2015 May;37(5):746-54. doi: 10.1002/hed.23634. Epub 2014 May 5.
BACKGROUND
Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a rare cancer of thymic origin with little information available for treating clinicians.
METHODS
We performed a comprehensive literature search and updates were requested from all authors. We report one recent case.
RESULTS
We present the most comprehensive review of the clinical literature for SETTLE. We identified 41 published cases. SETTLE usually presents as an asymptomatic neck mass. Most patients successfully underwent surgical resection of the primary tumor. The mean latency to develop metastasis was 10 years. SETTLE is uniformly responsive to radiotherapy and combination chemotherapy in the rare cases where response data are available.
CONCLUSION
Although SETTLE is initially indolent, it has the capacity to metastasize late in its course. The malignant potential of this tumor might be underestimated because of the lack of long-term follow-up. In cases in which complete surgical resection is not possible, radiotherapy or combination chemotherapy is effective.
背景
具有胸腺样分化的梭形上皮肿瘤（SETTLE）是一种罕见的胸腺源性癌症，可供临床医生参考的治疗信息很少。
方法
我们进行了全面的文献检索，并要求所有作者提供更新信息。我们报告了1例近期病例。
结果
我们对SETTLE的临床文献进行了最全面的综述。我们确定了41例已发表的病例。SETTLE通常表现为无症状的颈部肿块。大多数患者成功地接受了原发性肿瘤的手术切除。发生转移的平均潜伏期为10年。在有反应数据的罕见病例中，SETTLE对放疗和联合化疗均有反应。
结论
尽管SETTLE最初进展缓慢，但它有在病程后期发生转移的能力。由于缺乏长期随访，这种肿瘤的恶性潜能可能被低估。在无法进行完整手术切除的病例中，放疗或联合化疗是有效的。
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