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何时该满足于“SETTLE”！从我们的病例中学到的一课。

When to settle for SETTLE! A lesson learned from our cases.

作者信息

Nagarjun Bangalore Rammohan, Mehta Shailee, Gandhi Jahnavi, Trivedi Priti, Rathod Priyank

机构信息

Gujarat Cancer Research Institute (GCRI), Ahmedabad, Gujarat, India.

出版信息

Thyroid Res. 2024 Mar 4;17(1):6. doi: 10.1186/s13044-023-00189-x.

DOI:10.1186/s13044-023-00189-x
PMID:38438897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10913219/
Abstract

Spindle epithelial tumor with thymic like elements (SETTLE) is a biphasic tumor composed of epithelial and spindle cell components. It is an uncommon indolent tumor arising in the thyroid gland and most commonly affects the children and young adults. This entity is mostly overlooked because of its rarity and diagnostic difficulty on morphology. We discuss two cases of SETTLE with varied presentation, diagnostic challenges and lessons learnt from them.SETTLE should be considered as a differential especially when dealing with a thyroid lesion in young and adolescent. The article discusses the histologic details and common mimickers to be borne in mind aiding in arrival at the final diagnosis on biopsy specimens.

摘要

伴胸腺样成分的梭形上皮肿瘤（SETTLE）是一种由上皮和梭形细胞成分组成的双相肿瘤。它是一种罕见的惰性肿瘤，发生于甲状腺，最常见于儿童和年轻人。由于其罕见性以及形态学诊断困难，该实体大多被忽视。我们讨论两例表现各异的SETTLE病例、诊断挑战以及从中吸取的经验教训。尤其是在处理青少年甲状腺病变时，应将SETTLE视为鉴别诊断之一。本文讨论了组织学细节以及需要牢记的常见误诊情况，有助于对活检标本做出最终诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/984fb31fcb32/13044_2023_189_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/9d9b82e9e50e/13044_2023_189_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/0ba7217ade74/13044_2023_189_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/984fb31fcb32/13044_2023_189_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/9d9b82e9e50e/13044_2023_189_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/0ba7217ade74/13044_2023_189_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c7f/10913219/984fb31fcb32/13044_2023_189_Fig3_HTML.jpg

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Giant Thyroid Fibrosarcoma- A Case Report.巨大甲状腺纤维肉瘤——病例报告
Iran J Otorhinolaryngol. 2020 Mar;32(109):109-112. doi: 10.22038/ijorl.2019.39741.2310.
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Spindle epithelial tumour with thymus-like differentiation: report of two cases.伴胸腺样分化的梭形上皮肿瘤：2例报告
Ann R Coll Surg Engl. 2020 Feb;102(2):e33-e35. doi: 10.1308/rcsann.2019.0116. Epub 2019 Sep 18.
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Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE): A Case Report.
Fetal Pediatr Pathol. 2019 Oct;38(5):399-405. doi: 10.1080/15513815.2019.1600625. Epub 2019 Apr 18.
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A Rare Primary Tumor of the Thyroid Gland: A New Case of Leiomyoma and Literature Review.甲状腺罕见原发性肿瘤：平滑肌瘤一例新病例及文献综述
Clin Med Insights Oncol. 2018 Nov 26;12:1179554918813535. doi: 10.1177/1179554918813535. eCollection 2018.
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Spindle epithelial tumor with thymus-like differentiation of the thyroid in a 70-year-old man.一名70岁男性甲状腺的伴胸腺样分化的梭形上皮肿瘤。
Ann Surg Treat Res. 2018 Jun;94(6):337-341. doi: 10.4174/astr.2018.94.6.337. Epub 2018 May 29.
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Cytologic findings of spindle epithelial tumor with thymus-like elements.伴有胸腺样成分的梭形上皮肿瘤的细胞学表现。
Laryngoscope. 2018 Feb;128(2):E78-E82. doi: 10.1002/lary.27020. Epub 2017 Nov 29.
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Indian J Surg Oncol. 2017 Jun;8(2):231-233. doi: 10.1007/s13193-016-0607-0. Epub 2016 Dec 17.
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