Qian Deyun, Zhang Junliang
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P. R., China.
Chem Rec. 2014 Apr;14(2):280-302. doi: 10.1002/tcr.201300039. Epub 2014 Feb 20.
This account describes our recent efforts devoted to gold chemistry since 2009. Based on furyl-Au 1,3-dipole analogues and related gold carbene intermediates, a rich variety of gold-catalyzed cascade reactions have been developed, which provide facile access to a diverse range of novel carbo- and heterocycles. In these reactions, the selectivity can be well controlled by the catalyst (ligand and metal), substrate or reagent. In addition, we have also developed the corresponding enantioselective variants, which are guided by bis(phosphinegold) complexes derived from axially chiral scaffolds and asymmetric gold/chiral Brønsted acid relay catalysis.
本报告描述了我们自2009年以来在金化学方面的最新研究成果。基于呋喃基-金1,3-偶极类似物及相关的金卡宾中间体，已开发出多种金催化的串联反应，这些反应为合成各种新型碳环和杂环化合物提供了便捷途径。在这些反应中，选择性可通过催化剂（配体和金属）、底物或试剂得到很好的控制。此外，我们还开发了相应的对映选择性变体，其由源自轴手性骨架的双（膦金）配合物和不对称金/手性布朗斯特酸接力催化引导。
