Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2658-61. doi: 10.1002/anie.201400147.
Asymmetric intramolecular direct hydroarylation of α-ketoamides gives various types of optically active 3-substituted 3-hydroxy-2-oxindoles in high yields with complete regioselectivity and high enantioselectivities (84-98% ee). This is realized by the use of the cationic iridium complex Ir(cod)₂ and the chiral O-linked bidentate phosphoramidite (R,R)-Me-BIPAM.
不对称分子内直接氢芳基化反应可使各种类型的 α-酮酰胺以高产率、完全区域选择性和高对映选择性（84-98%ee）转化为各种类型的光学活性 3-取代 3-羟基-2-色满酮。这是通过使用阳离子铱配合物Ir(cod)₂和手性 O-连接双齿磷酰胺（R,R）-Me-BIPAM 实现的。
