Kröner Eleanore S J, Lamb Hildo J, Siebelink Hans-Marc J, Cannegieter Suzanne C, van den Boogaard Pieter J, van der Wall Ernst E, de Roos Albert, Westenberg Jos J M
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.
J Magn Reson Imaging. 2014 Aug;40(2):287-93. doi: 10.1002/jmri.24470. Epub 2013 Nov 13.
To explore differences in arterial stiffness of the aorta and carotid artery, assessed by pulse wave velocity (PWV), to evaluate the blood flow volume distribution towards the carotid circulation and to assess the effect of aging on the coupling between aortic and carotid PWV using velocity-encoded magnetic resonance imaging (MRI).
Sixteen adult younger volunteers (age <30 years) and 16 older volunteers (age >45 years) underwent 3T MRI examination to assess aortic and carotid flow volumes and PWV using the transit time method.
Aortic versus carotid PWV-ratio was 1.2 for younger volunteers and 0.95 for older volunteers, demonstrating leveling of wall stiffness. Furthermore, flow volume per minute in the internal carotid artery was lower for older versus younger volunteers (mean volume 177 ± 42 mL/min/m(2) vs. 147 ± 32 mL/min/m(2), P = 0.028), whereas aorta and common carotid artery flow volumes were not different. Consequently, the fraction of blood flow volume towards the brain was smaller for older versus younger volunteers (61 ± 9% versus 71 ± 8%, P = 0.002).
PWV-leveling between aorta and carotid artery at older age is associated with a reduction in blood flow volume towards the brain. Velocity-encoded MRI can be used to evaluate PWV and flow volume distribution in the aortic arch and the carotid circulation.
通过脉搏波速度（PWV）评估来探讨主动脉和颈动脉的动脉僵硬度差异，评估流向颈动脉循环的血流量分布，并使用速度编码磁共振成像（MRI）评估衰老对主动脉和颈动脉PWV耦合的影响。
16名年轻成年志愿者（年龄<30岁）和16名老年志愿者（年龄>45岁）接受了3T MRI检查，采用通过时间法评估主动脉和颈动脉的血流量及PWV。
年轻志愿者的主动脉与颈动脉PWV比值为1.2，老年志愿者为0.95，表明血管壁僵硬度趋于平稳。此外，老年志愿者颈内动脉每分钟的血流量低于年轻志愿者（平均血流量177±42 mL/min/m²对147±32 mL/min/m²，P = 0.028），而主动脉和颈总动脉的血流量没有差异。因此，老年志愿者流向大脑的血流量占比低于年轻志愿者（61±9%对71±8%，P = 0.002）。
老年时主动脉和颈动脉之间的PWV趋于平稳与流向大脑的血流量减少有关。速度编码MRI可用于评估主动脉弓和颈动脉循环中的PWV及血流量分布。
