核酸递送中的可生物还原聚阳离子：过去、现在和未来趋势
Bioreducible polycations in nucleic acid delivery: past, present, and future trends.
作者信息
Oupický David, Li Jing
机构信息
Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Durham Research Center, 985830 Nebraska Medical Center, Omaha, NE 68198-5830, USA.
出版信息
Macromol Biosci. 2014 Jul;14(7):908-22. doi: 10.1002/mabi.201400061. Epub 2014 Mar 28.
Abstract
Polycations that are degradable by reduction of disulfide bonds are developed for applications in delivery of nucleic acids. This Feature Article surveys methods of synthesis of bioreducible polycations and discusses current understanding of the mechanism of action of bioreducible polyplexes. Emphasis is placed on the relationship between the biological redox environment and toxicity, trafficking, transfection activity, and in vivo behavior of bioreducible polycations and polyplexes.
摘要
可通过二硫键还原降解的聚阳离子被开发用于核酸递送。这篇专题文章综述了生物可还原聚阳离子的合成方法，并讨论了目前对生物可还原多聚体作用机制的理解。重点在于生物氧化还原环境与生物可还原聚阳离子及多聚体的毒性、转运、转染活性和体内行为之间的关系。
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