Elenga Narcisse, Cuadro Emma, Martin Elise, Cohen-Addad Nicole, Basset Thierry
Pediatric Unit, Cayenne Medical Center, Andrée Rosemon Hospital, Rue des Flamboyants, BP 6006, 97306 Cayenne Cedex, French Guiana.
Pediatric Unit, Kourou Medical Center, Avenue des îles, BP 703, 97310 Kourou, French Guiana.
Int J Pediatr. 2014;2014:213681. doi: 10.1155/2014/213681. Epub 2014 Jan 19.
A matched case-control study was performed in order to identify some associated factors for ACS or to confirm the published data. Controls were children hospitalized during the same period for pain crisis who did not develop an ACS during hospitalization. Between January 2006 and October 2010, there were 24 episodes of ACS distributed among 19 patients (8 girls and 11 boys). The median age was 7.5 years (range: 3 to 17 years) for the cases and 7 years (range: 3-18 years) for the controls. Four cases and 11 controls were treated with hydroxyurea (HU). In 75% of the cases, the ACS had arisen 24-72 hours following admission. The independent factors associated with ACS were average Hb rate <8 g/dL (OR = 4.96, 95% CI = 1.29-27.34, and P = 0.04), annual number of hospitalizations >3 (OR = 5.44, 95% CI = 3.59-8.21, and P = 0.003), average length of hospitalization >7 days (OR = 3.69, 95% CI = 3.59-8.21, and P = 0.003), and a pathological transthoracic echocardiography (TTE) (OR = 13.77, 95% CI = 2.07-91.46, and P = 0.003). Although the retrospective design and small sample size are weaknesses of the present study, these results are consistent with those of previous studies and allowed identifying associated factors such as a pathological TTE.
为了确定急性胸综合征（ACS）的一些相关因素或证实已发表的数据，进行了一项匹配病例对照研究。对照为同期因疼痛危象住院且住院期间未发生ACS的儿童。2006年1月至2010年10月期间，19例患者（8名女孩和11名男孩）共发生24次ACS发作。病例组的中位年龄为7.5岁（范围：3至17岁），对照组为7岁（范围：3至18岁）。4例病例和11例对照接受了羟基脲（HU）治疗。75%的病例在入院后24 - 72小时出现ACS。与ACS相关的独立因素为平均血红蛋白率<8 g/dL（OR = 4.96，95%CI = 1.29 - 27.34，P = 0.04）、年住院次数>3（OR = 5.44，95%CI = 3.59 - 8.21，P = 0.003）、平均住院时间>7天（OR = 3.69，95%CI = 3.59 - 8.21，P = 0.003）以及经胸超声心动图（TTE）检查结果异常（OR = 13.77，95%CI = 2.07 - 91.46，P = 0.003）。尽管本研究存在回顾性设计和样本量小的缺点，但这些结果与先前研究一致，并有助于确定如TTE检查结果异常等相关因素。
