Scheinman Robert
University of Colorado Denver, School of Pharmacy, Department of Pharmaceutical Sciences, Aurora, CO 80045;
For Immunopathol Dis Therap. 2013 Apr 1;4(2):93-110. doi: 10.1615/ForumImmunDisTher.2013008408.
NF-κB has long been known to play an important role in autoimmune diseases such as rheumatoid arthritis (RA). Indeed, as our understanding of how NF-κB is utilized has increased, we have been hard put to find a process not associated with this transcription factor family in some way. However, new data originating, in part, from genome-wide association studies have demonstrated that very specific alterations in components of the NF-κB pathway are sufficient to confer increased risk of developing disease. Here we review the data which have identified specific components of the NF-κB pathway, and consider what is known of their mechanisms of action and how these mechanisms might play into the disease process. In addition, the use of genetic information to predict RA is considered.
长期以来，人们一直认为核因子-κB（NF-κB）在类风湿性关节炎（RA）等自身免疫性疾病中发挥着重要作用。事实上，随着我们对NF-κB作用方式的理解不断加深，我们很难找到一个与这个转录因子家族毫无关联的过程。然而，部分源于全基因组关联研究的新数据表明，NF-κB信号通路成分的非常特定的改变足以增加患疾病的风险。在此，我们回顾了已确定NF-κB信号通路特定成分的数据，并思考了它们的作用机制以及这些机制如何影响疾病进程。此外，还考虑了利用遗传信息来预测RA的情况。
