综述：女性生殖代谢：调节机制与临床意义。
Minireview: Metabolism of female reproduction: regulatory mechanisms and clinical implications.
作者信息
Seli Emre, Babayev Elnur, Collins Stephen C, Nemeth Gabor, Horvath Tamas L
机构信息
Department of Obstetrics, Gynecology, and Reproductive Sciences (E.S., E.B., S.C., T.L.H.), Yale School of Medicine, New Haven, Connecticut 06520; Department of Obstetrics and Gynecology (G.N., T.L.H.), University of Szeged, Faculty of Medicine, Szeged, Hungary 6701; Department of Comparative Medicine (T.L.H.), Yale School of Medicine, New Haven, Connecticut 06520; and the Department of Neurobiology (T.L.H.), Yale School of Medicine, New Haven, Connecticut 06520.
出版信息
Mol Endocrinol. 2014 Jun;28(6):790-804. doi: 10.1210/me.2013-1413. Epub 2014 Mar 28.
Abstract
Female fertility is highly dependent on successful regulation of energy metabolism. Central processes in the hypothalamus monitor the metabolic state of the organism and, together with metabolic hormones, drive the peripheral availability of energy for cellular functions. In the ovary, the oocyte and neighboring somatic cells of the follicle work in unison to achieve successful metabolism of carbohydrates, amino acids, and lipids. Metabolic disturbances such as anorexia nervosa, obesity, and diabetes mellitus have clinically important consequences on human reproduction. In this article, we review the metabolic determinants of female reproduction and their role in infertility.
摘要
女性生育能力高度依赖于能量代谢的成功调节。下丘脑的核心过程监测机体的代谢状态，并与代谢激素一起驱动能量在外周的供应，以维持细胞功能。在卵巢中，卵母细胞和卵泡周围的体细胞协同工作，以实现碳水化合物、氨基酸和脂质的成功代谢。诸如神经性厌食症、肥胖症和糖尿病等代谢紊乱对人类生殖具有重要的临床影响。在本文中，我们综述了女性生殖的代谢决定因素及其在不孕症中的作用。
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