Xiong Yu-Ying, Zhu Hai-Ying, Shi Ruo-Jin, Wu Yun-Feng, Fan Yong, Jin Long
Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Department of Reproductive Health and Infertility, Guangdong Women and Children Hospital, Guangzhou, 511400, China.
Heliyon. 2024 Sep 28;10(19):e38551. doi: 10.1016/j.heliyon.2024.e38551. eCollection 2024 Oct 15.
Glucose is a major energy substrate for cellular life activities, and its metabolic pathways include glycolysis, the pentose phosphate pathway, the hexosamine biosynthesis pathway, and the polyol pathway. Here, we review the glucose uptake pathways, metabolic characteristics, glucose transport, glucose metabolism-related enzymes, and biological importance in mammalian oocyte maturation, early embryo development, and embryonic stem cell proliferation and differentiation. Moreover, the interrelationships among glucose metabolism, female reproduction-related diseases and assisted reproductive technologies are focused. In addition, we review a number of analytical methodologies with the intention to integrate a multi-tiered strategy that encompasses cutting-edge metabolomics, artificial intelligence, epigenetics, and morphological assessments, setting the stage for a pivotal approach to cultivating high-caliber embryos in the future.
葡萄糖是细胞生命活动的主要能量底物，其代谢途径包括糖酵解、磷酸戊糖途径、己糖胺生物合成途径和多元醇途径。在此，我们综述了葡萄糖摄取途径、代谢特征、葡萄糖转运、葡萄糖代谢相关酶以及在哺乳动物卵母细胞成熟、早期胚胎发育以及胚胎干细胞增殖与分化中的生物学重要性。此外，还重点阐述了葡萄糖代谢、女性生殖相关疾病与辅助生殖技术之间的相互关系。另外，我们还综述了一些分析方法，旨在整合一种多层次策略，该策略涵盖前沿代谢组学、人工智能、表观遗传学和形态学评估，为未来培育高质量胚胎的关键方法奠定基础。
