Zhang Jie, Xiao Yan, Zhang Xian-Wen, Gao Zhi-Qing, Han Jing-Hui
Department of Endocrinology, No. 153 of Central Hospital of People's Liberation Army , Zhengzhou , China .
Ren Fail. 2014 Jul;36(6):974-8. doi: 10.3109/0886022X.2014.900426. Epub 2014 Mar 31.
Relationship between methylenetetrahydrofolate reductase (MTHFR) A1298C gene polymorphism and type 2 diabetic nephropathy (T2DN) risk is still unclear. This study was performed to evaluate if there is an association between the MTHFR A1298C gene polymorphism and T2DN risk using meta-analysis. The relevant reports were searched and identified from PubMed, Cochrane Library on 1 October 2013, and eligible studies were included and synthesized. Eight reports were recruited into this meta-analysis for the association of the MTHFR A1298C gene polymorphism with T2DN risk. The MTHFR A1298C C allele or CC genotype was shown to be not associated with T2DN risk (C allele: OR = 0.76, 95% CI: 0.43-1.34, p = 0.34; CC genotype: OR = 1.18, 95% CI: 0.63-2.22, p = 0.60). Interestingly, AA genotype was associated with the T2DN risk (OR = 0.68, 95% CI: 0.49-0.96, p = 0.03). In the sensitivity analysis according to the Hardy-Weinberg equilibrium (HWE), the results were consistent with those in non-sensitivity analysis. However, in the sensitivity analysis according to the control source from hospital, sample size of case (≥ 100), sample size of case (<100), the MTHFR A1298C gene polymorphism was not associated with T2DN risk. In conclusion, the MTHFR A1298C gene polymorphism was not associated with T2DN risk. However, additional studies are required to firmly establish a correlation between the MTHFR A1298C gene polymorphism and T2DN risk.
亚甲基四氢叶酸还原酶（MTHFR）A1298C基因多态性与2型糖尿病肾病（T2DN）风险之间的关系仍不明确。本研究旨在通过荟萃分析评估MTHFR A1298C基因多态性与T2DN风险之间是否存在关联。于2013年10月1日从PubMed、Cochrane图书馆检索并识别相关报告，纳入并综合符合条件的研究。八项报告被纳入本荟萃分析，以研究MTHFR A1298C基因多态性与T2DN风险的关联。结果显示，MTHFR A1298C的C等位基因或CC基因型与T2DN风险无关（C等位基因：OR = 0.76，95%CI：0.43 - 1.34，p = 0.34；CC基因型：OR = 1.18，95%CI：0.63 - 2.22，p = 0.60）。有趣的是，AA基因型与T2DN风险相关（OR = 0.68，95%CI：0.49 - 0.96，p = 0.03）。在根据哈迪 - 温伯格平衡（HWE）进行的敏感性分析中，结果与非敏感性分析一致。然而，在根据医院对照来源、病例样本量（≥100）、病例样本量（<100）进行的敏感性分析中，MTHFR A1298C基因多态性与T2DN风险无关。总之，MTHFR A1298C基因多态性与T2DN风险无关。然而，需要更多研究来明确建立MTHFR A1298C基因多态性与T2DN风险之间的相关性。
