Grose Charles, Adams Harold P
Division of Infectious Diseases/Virology, Children's Hospital, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Expert Rev Anti Infect Ther. 2014 May;12(5):527-30. doi: 10.1586/14787210.2014.904203. Epub 2014 Mar 28.
This editorial will assess a proposed link between herpes zoster ophthalmicus and subsequent stoke. Herpes zoster (also called shingles) is caused by varicella-zoster virus (VZV), one of the 9 human herpesviruses. When children contract their primary VZV infection, virus often travels to the trigeminal ganglia and establishes latency. Upon reactivation in late adulthood, the same virus travels anterograde to cause herpes zoster ophthalmicus. In some people, the virus also traffics from the same trigeminal ganglion along afferent fibers around the carotid artery and its branches. Subsequently VZV-induced inflammation within the affected cerebral arteries leads to occlusion and stroke. In one retrospective analysis of people with herpes zoster ophthalmicus, there was a 4.5 fold higher risk of stroke than in a control group. Two other studies found a less compelling association.
本社论将评估眼部带状疱疹与随后中风之间的一种假定联系。带状疱疹（也称为蛇串疮）由水痘-带状疱疹病毒（VZV）引起，它是9种人类疱疹病毒之一。儿童初次感染VZV时，病毒常常会传播至三叉神经节并建立潜伏状态。在成年后期病毒重新激活时，同一病毒会顺行传播导致眼部带状疱疹。在一些人中，病毒还会从同一三叉神经节沿着颈动脉及其分支周围的传入纤维传播。随后，受影响脑动脉内由VZV引起的炎症会导致血管闭塞和中风。在一项针对眼部带状疱疹患者的回顾性分析中，中风风险比对照组高4.5倍。另外两项研究发现的关联则不那么令人信服。
