Department of Dermatology, Perelman Center for Advanced Medicine, University of Pennsylvania, South Pavilion, 1st Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Department of Dermatology, Wake Forest Baptist Health, 4618 Country Club Road, Winston-Salem, NC 27104, USA.
Dermatol Clin. 2014 Apr;32(2):173-81. doi: 10.1016/j.det.2013.12.005. Epub 2014 Jan 22.
Central centrifugal cicatricial alopecia is an inflammatory type of central scalp hair loss seen primarily in women of African descent. The prevalence is unknown, but may vary from 2.7% to 5.7% and increases with age. This review outlines the history and current beliefs and identifies clues for future research for this enigmatic condition. Despite that the cause of central centrifugal cicatricial alopecia is unknown, research is ongoing. The role of cytokeratins, androgens, genetics, and various possible sources of chronic inflammation in disease pathogenesis remain to be elucidated.
中央离心性瘢痕性脱发是一种主要见于非裔女性的炎症性中央头皮脱发。其患病率未知，但可能在 2.7%至 5.7%之间，并随年龄增长而增加。本综述概述了该疾病的历史和当前的观点，并确定了未来研究的线索。尽管中央离心性瘢痕性脱发的病因尚不清楚，但研究仍在进行中。细胞角蛋白、雄激素、遗传和各种可能的慢性炎症来源在疾病发病机制中的作用仍有待阐明。
