综述：植物线粒体中的DNA复制
Minireview: DNA replication in plant mitochondria.
作者信息
Cupp John D, Nielsen Brent L
机构信息
Department of Microbiology & Molecular Biology, Brigham Young University, Provo, UT 84602, United States.
出版信息
Mitochondrion. 2014 Nov;19 Pt B:231-7. doi: 10.1016/j.mito.2014.03.008. Epub 2014 Mar 26.
Abstract
Higher plant mitochondrial genomes exhibit much greater structural complexity compared to most other organisms. Unlike well-characterized metazoan mitochondrial DNA (mtDNA) replication, an understanding of the mechanism(s) and proteins involved in plant mtDNA replication remains unclear. Several plant mtDNA replication proteins, including DNA polymerases, DNA primase/helicase, and accessory proteins have been identified. Mitochondrial dynamics, genome structure, and the complexity of dual-targeted and dual-function proteins that provide at least partial redundancy suggest that plants have a unique model for maintaining and replicating mtDNA when compared to the replication mechanism utilized by most metazoan organisms.
摘要
与大多数其他生物相比，高等植物的线粒体基因组呈现出更大的结构复杂性。与特征明确的后生动物线粒体DNA（mtDNA）复制不同，目前对参与植物mtDNA复制的机制和蛋白质的了解仍不清楚。已经鉴定出几种植物mtDNA复制蛋白，包括DNA聚合酶、DNA引发酶/解旋酶和辅助蛋白。线粒体动力学、基因组结构以及提供至少部分冗余的双靶向和双功能蛋白的复杂性表明，与大多数后生动物利用的复制机制相比，植物在维持和复制mtDNA方面具有独特的模式。
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