Lamke Jan-Peter, Daniels Judith K, Dörfel Denise, Gaebler Michael, Abdel Rahman Rasha, Hummel Falk, Erk Susanne, Walter Henrik
Division of Mind and Brain Research, Department of Psychiatry & Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany; Department of Psychology, Humboldt University of Berlin, Berlin, Germany.
Division of Mind and Brain Research, Department of Psychiatry & Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany; Clinic for Psychosomatic Medicine and Psychotherapy, Otto-von-Guericke University Magdeburg, Magdeburg, Germany.
PLoS One. 2014 Mar 28;9(3):e93098. doi: 10.1371/journal.pone.0093098. eCollection 2014.
Task-rest interactions, defined as the modulation of brain activation during fixation periods depending on the preceding stimulation and experimental manipulation, have been described repeatedly for different cognitively demanding tasks in various regions across the brain. However, task-rest interactions in emotive paradigms have received considerably less attention. In this study, we therefore investigated task-rest interactions evoked by the induction and instructed regulation of negative emotion. Whole-brain, functional MRI data were acquired from 55 healthy participants. Two-level general linear model statistics were computed to test for differences between conditions, separately for stimulation and for fixation periods, as well as for interactions between stimulation and fixation (task-rest interactions). Results showed that the regulation of negative emotion led to reverse task-rest interactions (decreased activation during stimulation but increased activation during fixation) in the amygdala as well as in visual cortex regions and to concordant task-rest interactions (increased activation during both, stimulation and fixation) in the dorsolateral prefrontal cortex as well as in a number of brain regions at the intersection of the default mode and the dorsal attention networks. Thus, this first whole-brain investigation of task-rest interactions following the induction and regulation of negative emotion identified a widespread specific modulation of brain activation in regions subserving emotion generation and regulation as well as regions implicated in attention and default mode.
任务-静息交互作用，定义为在注视期内大脑激活的调制，其取决于先前的刺激和实验操作，已在大脑各个区域针对不同认知需求任务被反复描述。然而，情绪范式中的任务-静息交互作用受到的关注要少得多。因此，在本研究中，我们调查了由负面情绪的诱发和指令调节所引发的任务-静息交互作用。从55名健康参与者获取了全脑功能磁共振成像数据。计算了两级一般线性模型统计量，以分别测试刺激期和注视期条件之间的差异，以及刺激和注视之间的交互作用（任务-静息交互作用）。结果表明，负面情绪调节导致杏仁核以及视觉皮层区域出现反向任务-静息交互作用（刺激期激活降低但注视期激活增加），并导致背外侧前额叶皮层以及默认模式和背侧注意网络交叉处的一些脑区出现一致的任务-静息交互作用（刺激期和注视期激活均增加）。因此，这项对负面情绪诱发和调节后的任务-静息交互作用的首次全脑研究，确定了在参与情绪产生和调节的区域以及与注意力和默认模式相关的区域中，大脑激活存在广泛的特定调制。
