Kragel Philip A, Zucker Nancy L, Covington Virginia E, LaBar Kevin S
Department of Psychology and Neuroscience, Duke University, Durham, NC, 27708 USA, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27710 USA, and Duke Center for Eating Disorders, Duke University School of Medicine, Durham, NC, 27710 USA.
Department of Psychology and Neuroscience, Duke University, Durham, NC, 27708 USA, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27710 USA, and Duke Center for Eating Disorders, Duke University School of Medicine, Durham, NC, 27710 USA Department of Psychology and Neuroscience, Duke University, Durham, NC, 27708 USA, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27710 USA, and Duke Center for Eating Disorders, Duke University School of Medicine, Durham, NC, 27710 USA Department of Psychology and Neuroscience, Duke University, Durham, NC, 27708 USA, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27710 USA, and Duke Center for Eating Disorders, Duke University School of Medicine, Durham, NC, 27710 USA.
Soc Cogn Affect Neurosci. 2015 Feb;10(2):240-7. doi: 10.1093/scan/nsu050. Epub 2014 Mar 28.
Social decision making is guided by the ability to intuitively judge personal attributes, including analysis of facial features to infer the trustworthiness of others. Although the neural basis for trustworthiness evaluation is well characterized in adults, less is known about its development during adolescence. We used event-related functional magnetic resonance imaging to examine age-related changes in neural activation and functional connectivity during the evaluation of trust in faces in a sample of adolescent females. During scanning, participants viewed masked presentations of faces and rated their trustworthiness. Parametric modeling of trust ratings revealed enhanced activation in amygdala and insula to untrustworthy faces, effects which peaked during mid-adolescence. Analysis of amygdala functional connectivity demonstrated enhanced amygdala-insula coupling during the evaluation of untrustworthy faces. This boost in connectivity was attenuated during mid-adolescence, suggesting a functional transition within face-processing circuits. Together, these findings underscore adolescence as a period of reorganization in neural circuits underlying socioemotional behavior.
社会决策受直观判断个人特质能力的引导，包括对面部特征进行分析以推断他人的可信赖程度。尽管成年人中评估可信赖程度的神经基础已得到充分表征，但对于其在青春期的发展情况却知之甚少。我们使用事件相关功能磁共振成像技术，在一组青春期女性样本中，研究在对面部信任度评估过程中神经激活和功能连接的年龄相关变化。在扫描过程中，参与者观看面部的蒙版呈现并对其可信赖程度进行评分。对信任评分的参数建模显示，杏仁核和脑岛对不可信赖面孔的激活增强，这种效应在青春期中期达到峰值。对杏仁核功能连接的分析表明，在评估不可信赖面孔时，杏仁核与脑岛的耦合增强。这种连接增强在青春期中期减弱，表明面部处理回路内发生了功能转变。这些发现共同强调青春期是社会情感行为背后神经回路重组的时期。
