系统性硬化症中手指血管病变的管理：内皮素-1受体拮抗剂多疗程治疗的益处
Management of digital vasculopathy in systemic sclerosis: benefits of multiple courses of endothelin-1 receptor antagonists.
作者信息
Ngcozana Tanaka, Ong Voon, Denton Christopher Paul
机构信息
Royal Free Hospital, London, UK.
出版信息
BMJ Case Rep. 2014 Mar 28;2014:bcr2013203174. doi: 10.1136/bcr-2013-203174.
Abstract
Two patients with scleroderma and recurrent digital ulcers (DUs) were treated with bosentan for 6 months. Treatment was associated with a reduction in the number of new DUs; however, DUs recurred on treatment discontinuation. This case report illustrates the positive response of digital vasculopathy to bosentan and describes the benefits of multiple bosentan treatment courses in these patients.
摘要
两名患有硬皮病和复发性指端溃疡（DU）的患者接受波生坦治疗6个月。治疗与新发生的DU数量减少相关；然而，停药后DU复发。本病例报告阐述了指端血管病变对波生坦的阳性反应，并描述了在这些患者中多次使用波生坦治疗疗程的益处。
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本文引用的文献
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A prospective study of systemic sclerosis-related digital ulcers: prevalence, location, and functional impact.一项系统性硬化症相关手指溃疡的前瞻性研究：患病率、位置和功能影响。
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Low occurrence of digital ulcers in scleroderma patients treated with bosentan for pulmonary arterial hypertension: a retrospective case-control study.硬皮病患者肺动脉高压应用波生坦治疗后发生手指溃疡的频率较低：一项回顾性病例对照研究。
Clin Rheumatol. 2013 May;32(5):679-83. doi: 10.1007/s10067-013-2172-z. Epub 2013 Jan 24.
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Bosentan fosters microvascular de-remodelling in systemic sclerosis.波生坦促进系统性硬皮病的微血管重构。
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Bosentan in clinical practice for treating digital and other ischemic ulcers in Spanish patients with systemic sclerosis: IBER-DU cohort study.波生坦在西班牙系统性硬皮病患者治疗数字和其他缺血性溃疡中的临床应用：IBER-DU 队列研究。
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Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial.波生坦治疗系统性硬化症相关的手指溃疡：RAPIDS-2 随机、双盲、安慰剂对照试验结果。
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