金鸡纳生物碱衍生的带有多个氢键供体的双功能叔胺-硫脲催化丙二酸二乙酯对查耳酮的高对映选择性迈克尔加成反应。
Highly enantioselective Michael addition of diethyl malonate to chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.
作者信息
Liu Yulong, Wang Xie, Wang Xiaoyun, He Wei
机构信息
Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi'an 710032, P. R. China.
出版信息
Org Biomol Chem. 2014 May 28;12(20):3163-6. doi: 10.1039/c4ob00203b. Epub 2014 Mar 28.
PMID:24682148
Abstract
Chalcones are still challenge substrates in Michael reactions, and only limited success has been achieved. This work describes a highly enantioselective Michael addition of diethyl malonate with chalcones catalyzed by cinchona alkaloids-derivatived bifunctional tertiary amine-thioureas bearing multiple hydrogen-bonding donors.
摘要
查耳酮在迈克尔反应中仍然是具有挑战性的底物，目前仅取得了有限的成功。本文描述了一种由含有多个氢键供体的金鸡纳生物碱衍生的双功能叔胺-硫脲催化丙二酸二乙酯与查耳酮的高度对映选择性迈克尔加成反应。
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