带有多个氢键供体的手性胺-硫脲：乙酰丙酮对硝基烯烃不对称迈克尔加成反应的高效有机催化剂。
Chiral amine-thioureas bearing multiple hydrogen bonding donors: highly efficient organocatalysts for asymmetric Michael addition of acetylacetone to nitroolefins.
作者信息
Wang Chun-Jiang, Zhang Zhi-Hai, Dong Xiu-Qin, Wu Xiao-Jun
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, 430072, China.
出版信息
Chem Commun (Camb). 2008 Mar 28(12):1431-3. doi: 10.1039/b718949d. Epub 2008 Jan 23.
DOI:10.1039/b718949d
PMID:18338046
Abstract
New bifunctional organocatalysts amine-thioureas bearing multiple hydrogen bonding donors were synthesized and applied in catalytic asymmetric Michael addition of acetylacetone to aryl and alkyl nitroolefins. Multiple hydrogen bonding donors play a significant role in accelerating reactions, improving yields and enantioselectivities.
摘要
合成了带有多个氢键供体的新型双功能有机催化剂胺-硫脲，并将其应用于乙酰丙酮与芳基和烷基硝基烯烃的催化不对称迈克尔加成反应中。多个氢键供体在加速反应、提高产率和对映选择性方面发挥着重要作用。
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