Yamamoto Y, Sano K, Kimoto M
Department of Surgery, Kawasaki Medical School, Okayama, Japan.
Am Surg. 1989 Apr;55(4):252-6.
Thirty-two patients with anorectal cancer were treated with cryosurgery from April 1974 to August 1985. The purpose of the treatment was to provide palliative benefits to 27 patients. In one group (17 patients) who did have previous surgery, cryosurgery was used for the predominant symptoms of melena and/or obstruction. In the postoperative period, local bleeding was minimal, and palliation was judged significant. The survival time of this group ranged from 1 month to 18 months. In another group (10 patients) in whom recurrent cancer followed previous operative treatment, cryosurgery was used to control the local invasion and tumor bulk. All of these patients died within 17 months after recurrence was discovered. Nevertheless, treatment was judged to provide significant palliation. A small group (five patients) was treated with the intent to cure, and cryosurgical techniques were used as an adjunct to surgical excision. Four patients survived more than 8 years after the operation. Two of these patients died of illnesses other than cancer. The local destruction of an anorectal cancer by cryosurgery in these patients provided effective control of the tumor. Bleeding was controlled, and tumor bulk was reduced in size. All patients were treated without any complications caused by cryosurgery. This experience indicates that the cryosurgical technique provides therapeutic benefits for selected patients with anorectal cancer, especially those of high surgical risk.
1974年4月至1985年8月,32例肛管直肠癌患者接受了冷冻手术治疗。治疗目的是为27例患者提供姑息性治疗。在一组(17例患者)曾接受过手术的患者中,冷冻手术用于治疗黑便和/或梗阻等主要症状。术后局部出血极少,且判断姑息治疗效果显著。该组患者的生存时间为1个月至18个月。在另一组(10例患者)中,复发性癌症发生在先前的手术治疗之后,冷冻手术用于控制局部浸润和肿瘤体积。所有这些患者在发现复发后17个月内死亡。然而,治疗仍被判定提供了显著的姑息效果。一小部分(5例患者)接受了旨在治愈的治疗,冷冻手术技术被用作手术切除的辅助手段。4例患者术后存活超过8年。其中2例患者死于癌症以外的疾病。冷冻手术对这些患者肛管直肠癌的局部破坏有效控制了肿瘤。出血得到控制,肿瘤体积缩小。所有患者接受治疗时均未出现冷冻手术引起的任何并发症。这一经验表明,冷冻手术技术为选定的肛管直肠癌患者,尤其是手术风险高的患者提供了治疗益处。