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[直肠癌的姑息性冷冻手术]

[Palliative cryosurgery in rectal carcinoma].

作者信息

Meijer S, Jas B, de Lange E, Derksen E J

机构信息

Academisch Ziekenhuis Vrije Universiteit, afd. Heelkunde, Amsterdam.

出版信息

Ned Tijdschr Geneeskd. 1996 Aug 31;140(35):1766-70.

PMID:8927129
Abstract

OBJECTIVE

Analysis of palliative cryosurgery in rectal cancer patients.

DESIGN

Descriptive.

SETTING

Department of surgery, University Hospital Vrije Universiteit, Amsterdam, the Netherlands.

METHODS

Ninety-three patients (age: 45-92 years) underwent palliative cryosurgery for primary rectal cancer. They were excluded from surgical resection because of old age, accompanying disease(s), inoperability and the presence of hematogenous metastases. The palliative effect of cryosurgery on local symptoms was classified as good, moderate or none. The duration of palliation was calculated in relation to survival as a palliative index: the number of months of (moderate or good) palliation divided by the number of months of survival from the start of the treatment, multiplied by 100%.

RESULTS

In 58 patients (62%) there was complete relief of local symptoms with a palliative index of 87%. In 13 patients (14%) palliation was moderate and in 22 patients (24%) no palliation was achieved. The 50% survival duration in the 58 patients was 37 months. Especially symptoms of blood and/or mucous discharge could be easily alleviated. Good alleviation of local symptoms was associated with the extent of the primary tumour process. Palliative effect could be assessed after a few treatments. Patients with circular rectal tumours seldom had long term palliative effects of cryosurgery.

CONCLUSION

Cryosurgery for rectal cancer is a simple and safe treatment. It should be considered for alleviation of local symptoms in patients with rectal cancer who are unsuitable for radical surgery.

摘要

目的

分析直肠癌患者的姑息性冷冻手术。

设计

描述性研究。

地点

荷兰阿姆斯特丹自由大学大学医院外科。

方法

93例患者(年龄45 - 92岁)因原发性直肠癌接受了姑息性冷冻手术。由于年龄较大、伴有其他疾病、无法手术以及存在血行转移,他们被排除在手术切除之外。冷冻手术对局部症状的姑息效果分为良好、中等或无效果。将姑息治疗持续时间与生存时间相关计算为姑息指数:(中等或良好)姑息治疗的月数除以从治疗开始起的生存月数,再乘以100%。

结果

58例患者(62%)局部症状完全缓解,姑息指数为87%。13例患者(14%)姑息效果中等,22例患者(24%)未达到姑息效果。58例患者的50%生存时间为37个月。特别是便血和/或黏液便症状很容易得到缓解。局部症状的良好缓解与原发性肿瘤的范围有关。经过几次治疗后即可评估姑息效果。直肠环形肿瘤患者很少有冷冻手术的长期姑息效果。

结论

直肠癌冷冻手术是一种简单安全的治疗方法。对于不适合根治性手术的直肠癌患者,应考虑采用该方法缓解局部症状。

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Ned Tijdschr Geneeskd. 1996 Aug 31;140(35):1766-70.
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