丙泊酚预混利多卡因联合或不联合酮咯酸预处理（与安慰剂相比）对减轻丙泊酚注射痛的效果比较：一项针对成年韩国外科手术患者的前瞻性、随机、双盲、安慰剂对照研究。

Comparison of effect of premixed lidocaine in propofol with or without ketorolac pretreatment with placebo on reducing pain on injection of propofol: A prospective, randomized, double-blind, placebo-controlled study in adult Korean surgical patients.

作者信息

Yeo Jinseok, Jeon Younghoon, Kim Youngsoo, Ha Jaehyun, Baek Woonyi

机构信息

Department of Anesthesiology and Pain Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.

出版信息

Curr Ther Res Clin Exp. 2009 Oct;70(5):351-8. doi: 10.1016/j.curtheres.2009.10.001.

DOI:10.1016/j.curtheres.2009.10.001

PMID:24683243

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3967284/

Abstract

BACKGROUND

Pain on injection of propofol is a common adverse event.

OBJECTIVE

The aim of this study was to investigate the effect of a combination of ketorolac pretreatment and premixed lidocaine in propofol compared with placebo on propofol injection pain.

METHODS

In this prospective, randomized, double-blind, placebo-controlled study, Korean patients scheduled for elective plastic surgery were randomized to 1 of 3 groups. Group A received 15 mg ketorolac in saline IV as pretreatment. Groups B and C received 3 mL saline IV as pretreatment. Sixty seconds after pretreatment, groups A and B received a mixture of lidocaine 1% in propofol 1% at a 1:10 ratio and group C received propofol 1% alone. Pain during propofol injection was assessed on a 4-point scale (0 = none, 1 = mild, 2 = moderate, 3 = severe).

RESULTS

Ninety patients (41 men, 49 vvomen; mean age, 41.7 years; mean weight, 63 kg) completed the study. The overall incidence of pain on propofol injection was significantly lower in groups A (16.7%) and B (36.7%) than in group C (83.3%; both, P < 0.001). There was no significant difference in the incidence of pain between groups A and B. However, the patients in group A reported a significantly lower incidence of moderate (0% vs 33.3%; P < 0.001) and severe pain (0% vs 20%; P = 0.024) compared with those in group C. There were no significant differences in the incidences of moderate and severe pain between the B and C groups.

CONCLUSIONS

In this Korean population, premixed lidocaine in propofol with or without ketorolac pretreatment was associated with significantly less pain when compared with placebo. The combination of ketorolac pretreatment and premixed lidocaine in propofol was more effective in decreasing the incidence of moderate or severe pain compared with placebo.

摘要

背景

丙泊酚注射痛是一种常见的不良事件。

目的

本研究旨在探讨酮咯酸预处理联合预混利多卡因的丙泊酚与安慰剂相比对丙泊酚注射痛的影响。

方法

在这项前瞻性、随机、双盲、安慰剂对照研究中，计划进行择期整形手术的韩国患者被随机分为3组中的1组。A组静脉注射15mg酮咯酸生理盐水作为预处理。B组和C组静脉注射3mL生理盐水作为预处理。预处理60秒后，A组和B组接受1%利多卡因与1%丙泊酚按1:10比例混合的溶液，C组仅接受1%丙泊酚。丙泊酚注射期间的疼痛采用4级评分法评估（0 = 无，1 = 轻度，2 = 中度，3 = 重度）。

结果

90例患者（41例男性，49例女性；平均年龄41.7岁；平均体重63kg）完成了研究。丙泊酚注射痛的总体发生率在A组（16.7%）和B组（36.7%）显著低于C组（83.3%；P均<0.001）。A组和B组之间的疼痛发生率无显著差异。然而，与C组相比，A组患者中度疼痛（0%对33.3%；P<0.001）和重度疼痛（0%对20%；P = 0.024）的发生率显著更低。B组和C组之间中度和重度疼痛的发生率无显著差异。