Yull D N, Barkshire K F, Dexter T
Department of Anaesthetics, Wycombe General Hospital, High Wycombe, Bucks, UK.
Anaesthesia. 2000 Mar;55(3):284-7. doi: 10.1046/j.1365-2044.2000.01320.x.
We performed a randomised, double-blind, prospective trial to discover whether intravenous ketorolac 10 mg made up to 2 ml with saline, with or without venous occlusion for 2 min, reduces the pain on injection of propofol. In 90 patients, pain scores were obtained during injection of propofol following pretreatment of the vein with saline, ketorolac or ketorolac with venous occlusion. Pain on injection of ketorolac was more common than with saline (p = 0.02). The incidence of severe pain following propofol was reduced by ketorolac with venous occlusion (p = 0.019) compared with saline or ketorolac without venous occlusion. There was no difference in venous sequelae at 7 days postoperatively between the groups. Our results suggest that pain on injection of propofol may be related to release of local kininogens and that nonsteroidal anti-inflammatory drugs may have a role in reducing that pain.
我们进行了一项随机、双盲、前瞻性试验，以探究静脉注射10毫克酮咯酸并用生理盐水配制成2毫升，无论是否进行2分钟的静脉闭塞，是否能减轻丙泊酚注射时的疼痛。在90名患者中，在静脉分别用生理盐水、酮咯酸或酮咯酸加静脉闭塞预处理后，于丙泊酚注射期间获取疼痛评分。注射酮咯酸时的疼痛比用生理盐水时更常见（p = 0.02）。与生理盐水或未进行静脉闭塞的酮咯酸相比，酮咯酸加静脉闭塞可降低丙泊酚注射后严重疼痛的发生率（p = 0.019）。术后7天，各组之间的静脉后遗症无差异。我们的结果表明，丙泊酚注射时的疼痛可能与局部激肽原的释放有关，并且非甾体抗炎药可能在减轻该疼痛方面发挥作用。
