Müller F A, Hänny P E, Wichmann W, Fierz W, Dürsteler M R
Department of Neurology, University Hospital, Zurich, Switzerland.
Arch Neurol. 1989 Apr;46(4):367-71. doi: 10.1001/archneur.1989.00520400021013.
The clinical (disability) and paraclinical (visually evoked potential [VEP]/magnetic resonance imaging [MRI]) data of patients with definite or probable multiple sclerosis (MS) were compared with their cerebrospinal fluid (CSF) immunoglobulins taken within the same period of time. For patients with definite diagnosis by the Schumacher criteria (n = 61) we found significant correlations between CSF immunoglobulin content (absolute gamma-globulin value [aggv]) and quantified MRI factors (r = .47), between aggv and the sum of VEP latencies of both eyes (r = .53), and also between MRI and VEP changes (r = .62). This was not true for the patients with a probable MS diagnosis and for patients with first attacks. No correlations were evident between aggv and disability status or duration of the illness. The results give support to recent neuropathologic and experimental findings in animals indicating close pathogenic connections between CSF immunoglobulins and demyelination in MS.
将确诊或疑似多发性硬化症（MS）患者的临床（残疾情况）和辅助临床（视觉诱发电位[VEP]/磁共振成像[MRI]）数据与同期采集的脑脊液（CSF）免疫球蛋白进行比较。对于根据舒马赫标准确诊的患者（n = 61），我们发现脑脊液免疫球蛋白含量（绝对γ-球蛋白值[aggv]）与定量MRI因子之间存在显著相关性（r = 0.47），aggv与双眼VEP潜伏期总和之间存在显著相关性（r = 0.53），MRI与VEP变化之间也存在显著相关性（r = 0.62）。对于疑似MS诊断的患者和首次发作的患者，情况并非如此。aggv与残疾状态或病程之间没有明显的相关性。这些结果支持了近期在动物身上的神经病理学和实验研究结果，表明脑脊液免疫球蛋白与MS脱髓鞘之间存在密切的致病联系。
