a Biomedical, Chemical and Materials Engineering, San Jose State University , San Jose , CA , USA.
b Department of Bioengineering , Santa Clara University , Santa Clara , CA , USA.
Artif Cells Nanomed Biotechnol. 2015;43(6):390-7. doi: 10.3109/21691401.2014.897629. Epub 2014 Apr 1.
A simulation of tensile strength of various alginate-based hollow microfibers using FEA analysis has been conducted with the hypothesis of macroscopic isotropy and linear elastic-plastic behavior. Results of student t-tests indicated that there was no significant difference between the experimental and simulated tensile strengths (p = 0.37, α = 0.05), while there was a significant reduction in elasticity as a result of chitosan coating (p = 0.024, α = 0.05). The hypothesis of macroscopic isotropy was verified by highly correlated (R(2) ≥ 0.92) theoretical and experimental elongation at break measurements, findings that could be extended to the failure analysis of alginate microfibers used in regenerative medicine.
使用有限元分析对各种基于海藻酸盐的中空微纤维的拉伸强度进行了模拟，假设其具有宏观各向同性和线弹性-塑性行为。学生 t 检验的结果表明，实验和模拟的拉伸强度之间没有显著差异（p = 0.37，α = 0.05），而壳聚糖涂层导致弹性显著降低（p = 0.024，α = 0.05）。宏观各向同性的假设通过高度相关的（R²≥0.92）理论和实验断裂伸长率测量得到了验证，这一发现可以扩展到再生医学中使用的海藻酸盐微纤维的失效分析中。
