Coghlan John P
Office of the Dean of Medicine Dentistry and Health Science, The University of Melbourne, Melbourne, Victoria, Australia.
Clin Exp Pharmacol Physiol. 2014 Jun;41(6):381-91. doi: 10.1111/1440-1681.12236.
The origins of the Howard Florey Laboratories of Experimental Physiology, Department of Physiology, The University of Melbourne, are tied to the ground-breaking clinical work of Derek A Denton in 1947 and to the investigations of the initial scientific team into the control of salt and water balance in health and disease over the period 1947-1963 were Professor RD Wright, Drs JR Goding, IR McDonald, John P Coghlan, E Marelyn Wintour and John R Blair-West. An Act of Parliament in 1971 by the Victorian State Government formally established the Institute named after Howard Florey, the Australian Nobel Prize winner who isolated penicillin. The Howard Florey Laboratories/Institute quickly became an international leader in the scientific areas of the physiological control of body fluids and electrolyte balance, especially sodium regulation and the regulation of the secretion of aldosterone, the adrenal salt-retaining hormone; the micro measurement of hormones, in particular steroids and peptides; instinctive ingestive behaviour; fetal fluid regulation; hybridization histochemistry, and the hormone relaxin. Subsequently, the senior staff included, inter alia, Bruce Scoggins, Richard Weisinger, John McDougall, Brian Oldfield, Michael McKinley, Robin McAllen, Hugh Niall, Geoff Tregear and Felix Beck. During the 1990s, an explosion occurred in neuroscience and, in 1997, the Board made the strategic decision to change the focus of the Institute to brain disorders. From 1997 to 2007, Fred Mendelsohn steered the Florey to become one of Australia's premier brain research institutes and, under the current director (the eminent clinician and neuroscientist Geoffrey Donnan), this reputation has been further enhanced.
墨尔本大学理学院实验生理学霍华德·弗洛里实验室的起源，与德里克·A·丹顿1947年具有开创性的临床工作有关，也与1947年至1963年期间最初的科学团队对健康和疾病状态下盐和水平衡控制的研究有关。该团队成员包括RD·赖特教授、JR·戈丁博士、IR·麦克唐纳博士、约翰·P·科格伦、E·马雷林·温图尔和约翰·R·布莱尔-韦斯特。1971年，维多利亚州政府通过一项议会法案，正式设立了以分离出青霉素的澳大利亚诺贝尔奖获得者霍华德·弗洛里命名的研究所。霍华德·弗洛里实验室/研究所很快在体液生理控制和电解质平衡的科学领域成为国际领先者，尤其是钠调节以及肾上腺保盐激素醛固酮分泌的调节；激素的微量测量，特别是类固醇和肽类；本能摄食行为；胎儿液体调节；杂交组织化学，以及激素松弛素。随后，高级工作人员尤其包括布鲁斯·斯科金斯、理查德·魏辛格、约翰·麦克杜格尔、布莱恩·奥尔德菲尔德、迈克尔·麦金利、罗宾·麦卡伦、休·尼尔、杰夫·特里吉尔和费利克斯·贝克。在20世纪90年代，神经科学领域出现了迅猛发展，1997年，董事会做出战略决策，将研究所的重点转向脑部疾病。从1997年到2007年，弗雷德·门德尔松带领弗洛里研究所成为澳大利亚顶尖的脑研究机构之一，在现任所长（杰出的临床医生和神经科学家杰弗里·唐南）的领导下，这一声誉得到了进一步提升。
