Tursi Antonio
Gastroenterology Service, ASL BAT , Via Torino 49, 76123 Andria (BT) , Italy +39 0883 551094 ; +39 0883 1978210 ;
Expert Opin Pharmacother. 2014 May;15(7):1005-17. doi: 10.1517/14656566.2014.903922. Epub 2014 Mar 31.
Diverticular disease (DD) of the colon is a widespread disease, which shows worldwide increasing incidence and represents a significant burden for National Health Systems. The current guidelines claim that symptomatic uncomplicated DD (SUDD) has to be treated with spasmolithics and high-fiber diet, whereas both uncomplicated and complicated acute diverticulitis has to be treated with antibiotics. However, new physiopathological knowledge suggests that further treatment may be promising.
Pathogenetic and treatment studies on SUDD and acute diverticulitis published in PubMed, www.clinicaltrials.gov , and in the main International Congress were reviewed.
Although absorbable antibiotics and 5-aminosalycilic acid seem to be effective in treating SUDD, their role in preventing diverticulitis recurrence is still under debate. Antibiotic use in managing acute diverticulitis is at least questionable, and use of probiotics seems to be promising but need further robust studies to confirm the preliminary results.
结肠憩室病（DD）是一种广泛存在的疾病，其在全球范围内的发病率呈上升趋势，给国家卫生系统带来了沉重负担。当前指南指出，症状性非复杂性DD（SUDD）必须采用解痉药和高纤维饮食进行治疗，而无论是非复杂性还是复杂性急性憩室炎都必须使用抗生素进行治疗。然而，新的生理病理学知识表明，进一步的治疗可能是有前景的。
对发表于PubMed、www.clinicaltrials.gov以及主要国际会议上的关于SUDD和急性憩室炎的发病机制及治疗研究进行了综述。
尽管可吸收抗生素和5-氨基水杨酸似乎对治疗SUDD有效，但其在预防憩室炎复发中的作用仍存在争议。在急性憩室炎的治疗中使用抗生素至少是有疑问的，而使用益生菌似乎有前景，但需要进一步有力的研究来证实初步结果。
