Abel Yoann, Clerget Guillaume, Bourguignon-Igel Valérie, Salone Véronique, Rederstorff Mathieu
Université de Lorraine, CNRS, UMR 7365 IMoPA, Biopôle, 9, avenue de la forêt de Haye, 54506 Vandœuvre-lès-Nancy, France.
Med Sci (Paris). 2014 Mar;30(3):297-302. doi: 10.1051/medsci/20143003018. Epub 2014 Mar 31.
Small nucleolar RNAs or snoRNAs, principally implicated in post-transcriptional chemical modification of other RNAs, were among the first non-coding RNA identified, together with ribosomal and transfer RNA. Lately, snoRNA have been involved in various unexpected functions, which renewed researcher's interest for these molecules. SnoRNA processing into smaller functional RNA species (sdRNA for snoRNA-derived RNA) or into miRNA (sno-miR), snoRNA mediated regulation of messenger RNA alternative splicing or snoRNA links to human disorders, including cancers, are some of the topics developed in this review.
小核仁RNA（snoRNA）主要参与其他RNA的转录后化学修饰，它与核糖体RNA和转运RNA一起，是最早被鉴定出的非编码RNA之一。最近，snoRNA参与了各种意想不到的功能，这重新激发了研究人员对这些分子的兴趣。snoRNA加工成更小的功能性RNA种类（snoRNA衍生RNA的sdRNA）或加工成miRNA（sno-miR）、snoRNA介导的信使RNA可变剪接调控或snoRNA与包括癌症在内的人类疾病的关联，是本综述中探讨的一些主题。
