小核仁 RNA 的新功能。

New functions of small nucleolar RNAs.

机构信息

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia.

出版信息

Biochemistry (Mosc). 2013 Jun;78(6):638-50. doi: 10.1134/S0006297913060096.

Abstract

Small nucleolar RNAs (snoRNAs) are one of the most abundant and well-studied groups of non-coding RNAs. snoRNAs are mostly engaged in processing of rRNA. However, recent data indicate that snoRNAs are also involved in other processes including regulation of alternative splicing, translation and oxidative stress. snoRNAs are also involved in pathogenesis of some hereditary diseases and cancer. Therefore, the range of snoRNAs' functions is significantly wider than it has been assumed earlier.

摘要

小核仁 RNA（snoRNA）是最丰富和研究最透彻的非编码 RNA 之一。snoRNA 主要参与 rRNA 的加工。然而，最近的数据表明 snoRNA 还参与其他过程，包括调节可变剪接、翻译和氧化应激。snoRNA 还参与一些遗传性疾病和癌症的发病机制。因此，snoRNA 的功能范围比之前认为的要广泛得多。