Murray S R, Norman J E
Simpson Centre for Reproductive Health, Royal Infirmary Edinburgh, 47 Little France Crescent, UK.
MRC Centre for Reproductive Health, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh, UK.
Semin Fetal Neonatal Med. 2014 Aug;19(4):222-7. doi: 10.1016/j.siny.2014.03.001. Epub 2014 Mar 28.
The association between assisted reproduction technologies (ART) and multiple pregnancy is well-established, with a multiple birth rate of 24% in ART pregnancies. Multiple pregnancy is associated with significantly increased maternal and perinatal morbidity and mortality, as well as increased costs to the National Health Service. Evidence relating to the obstetric outcomes of ART twins versus naturally conceived twins is discussed in this review. Methods to reduce the risk of multiple births including elective single embryo transfer and multifetal pregnancy reduction are also discussed.
辅助生殖技术（ART）与多胎妊娠之间的关联已得到充分证实，ART妊娠的多胎出生率为24%。多胎妊娠与孕产妇和围产期发病率及死亡率显著增加以及国民医疗服务体系成本增加相关。本综述讨论了与ART双胞胎和自然受孕双胞胎的产科结局相关的证据。还讨论了降低多胎生育风险的方法，包括选择性单胚胎移植和多胎妊娠减胎术。
