多面几丁质/聚（乳酸-乙醇酸）共聚物复合纳米凝胶
Multifaceted chitin/poly(lactic-co-glycolic) acid composite nanogels.
作者信息
Rejinold N Sanoj, Biswas Raja, Chellan Gopi, Jayakumar R
机构信息
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Ponekkara, Kochi 682041, India.
Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Ponekkara, Kochi 682041, India.
出版信息
Int J Biol Macromol. 2014 Jun;67:279-88. doi: 10.1016/j.ijbiomac.2014.03.037. Epub 2014 Mar 28.
Cyto-compatible, 80nm sized chitin/PLGA composite nanogels (chit/PLGA-comp NGs) were prepared by regeneration method and characterized. The multifaceted chit/PLGA-comp NGs were surface modified with Au, Fe3O4, CdTe/ZnTe-QDs and umbelliferone, respectively. 185nm sized Au-chit/PLGA-comp NGs, 170nm sized QD-chit/PLGA-comp-NGs and 160nm sized Fe3O4-chit/PLGA-comp-NGs showed RF heating. The QD-chit/PLGA-comp-NGs and 180nm sized umb-chit/PLGA-comp-NGs were well uptaken by Escherichia coli, Staphylococcus aureus and Candida albicans. The chit/PLGA-comp NGs could be useful for microbial monitoring and RF application for cancer therapy. The preliminary data showed that multifaceted chit/PLGA-comp-NGs could be useful for hyperthermia for cancer treatment and microbial labelling and imaging.
通过再生方法制备了细胞相容性、尺寸为80nm的几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶（几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶）并对其进行了表征。多面几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶分别用金、四氧化三铁、碲化镉/碲化锌量子点和伞形酮进行了表面修饰。尺寸为185nm的金-几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶、尺寸为170nm的量子点-几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶和尺寸为160nm的四氧化三铁-几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶显示出射频加热。量子点-几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶和尺寸为180nm的伞形酮-几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶被大肠杆菌、金黄色葡萄球菌和白色念珠菌很好地摄取。几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶可用于微生物监测和用于癌症治疗的射频应用。初步数据表明，多面几丁质/聚乳酸-羟基乙酸共聚物复合纳米凝胶可用于癌症治疗的热疗以及微生物标记和成像。
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