Neethi H, Patil Shankargouda, Rao Roopa S
Postgraduate Student, Department of Oral Pathology, MS Ramaiah Dental College, Bengaluru, Karnataka, India, Phone: 91-9036610428 e-mail:
Senior Lecturer, Department of Oral Pathology, MS Ramaiah Dental College, Bengaluru, Karnataka, India.
J Contemp Dent Pract. 2013 Sep 1;14(5):801-5. doi: 10.5005/jp-journals-10024-1406.
Biochemical derangements of microelements although reported in oral cancer is poorly understood in oral submucous fbrosis (OSMF). Hence, the present study was carried out to estimate and compare the serum copper and zinc levels among different histopathological stages of OSMF with that of healthy controls.
Thirty histopathologically diagnosed cases of OSMF and 30 healthy controls reporting to MS Ramaiah Dental College and Hospital (MSRDCH), Bengaluru, were included in the study. The histopathological staging of OSMF was done as per criteria given by Pindborg and Sirsat (1966). Blood samples were collected and the serum copper and zinc levels were estimated using atomic absorption spectroscopy. The results were statistically analyzed using independent t-test and Kruskal-Wallis test.
The mean serum copper levels were increased (p < 0.0005) and zinc levels were decreased (p < 0.01) in OSMF patients when compared to that of controls. The mean serum copper levels showed an increasing trend from stage I to IV (p = 0.004) while zinc levels showed a decreasing trend from stage I to IV (p = 0.04) in OSMF patients.
The serum copper and zinc levels in OSMF showed a signifcant difference in comparison to that of controls and between the histopathological stages. These fndings indicate that serum copper and zinc may have a contributory role in the etiopathogenesis of OSMF.
Although the role of the trace elements as etiological factors is minor, derangements noted in the serum copper and zinc levels could be correlated with diseased progression and possibly explain the transformation of OSMF into malignancy. Thus, they can be used as prognostic markers and can be of value for proactive intervention.
尽管已有报道称口腔癌存在微量元素的生化紊乱，但口腔黏膜下纤维化（OSMF）中对此的了解却很少。因此，本研究旨在评估并比较OSMF不同组织病理学阶段与健康对照者的血清铜和锌水平。
本研究纳入了30例经组织病理学诊断的OSMF病例以及30名前往班加罗尔MS拉马亚牙科学院及医院（MSRDCH）就诊的健康对照者。OSMF的组织病理学分期按照平德伯格和西尔萨特（1966年）给出的标准进行。采集血样，并使用原子吸收光谱法测定血清铜和锌水平。结果采用独立t检验和克鲁斯卡尔 - 沃利斯检验进行统计学分析。
与对照组相比，OSMF患者的血清铜平均水平升高（p < 0.0005），锌水平降低（p < 0.01）。在OSMF患者中，血清铜平均水平从I期到IV期呈上升趋势（p = 0.004），而锌水平从I期到IV期呈下降趋势（p = 0.04）。
OSMF患者的血清铜和锌水平与对照组相比以及在不同组织病理学阶段之间均存在显著差异。这些发现表明血清铜和锌可能在OSMF的病因发病机制中起作用。
尽管微量元素作为病因因素的作用较小，但血清铜和锌水平的紊乱可能与疾病进展相关，并可能解释OSMF向恶性病变的转变。因此，它们可作为预后标志物，对积极干预具有重要价值。
