Varghese I, Sugathan C K, Balasubramoniyan G, Vijayakumar T
Oncology. 1987;44(4):224-7. doi: 10.1159/000226482.
Serum levels of copper and zinc were analysed in 50 patients with oral cancer, 50 patients with oral leucoplakia, and 50 patients with oral submucous fibrosis, and the values were compared with those of 50 normal healthy adult controls. There was a significant reduction in the serum copper and zinc levels in both oral submucous fibrosis and oral cancer. The copper/zinc ratio was found to be elevated in oral submucous fibrosis and depressed in oral cancer. The ratio may serve as a good indicator for the early detection of oral cancer.
对50例口腔癌患者、50例口腔白斑患者和50例口腔黏膜下纤维化患者的血清铜和锌水平进行了分析，并将这些值与50名正常健康成年对照者的值进行了比较。口腔黏膜下纤维化和口腔癌患者的血清铜和锌水平均显著降低。发现口腔黏膜下纤维化患者的铜/锌比值升高，而口腔癌患者的该比值降低。该比值可能是口腔癌早期检测的良好指标。
