Effect of monoclonal antihuman IgE on recombinant IgE(301-376) inhibition of specific IgE histamine release.
作者信息
Glovsky M M, Kebo D, Helm B A, Horvath S, Richards J A, Chretien I, Bencherau J, Gould H
机构信息
Department of Medicine, University of Southern California School of Medicine, Los Angeles.
出版信息
Int Arch Allergy Appl Immunol. 1989;88(1-2):203-5. doi: 10.1159/000234786.
To explore the binding domains of rCIgE(301-376) necessary for inhibition of passive transfer of rye grass and Chinese elm IgE to human basophils, we employed monoclonal antibodies known to bind to IgE(301-336), M-272, and to IgE(367-376), M-27. By preincubating M-272, but not M-27, with rCIgE(301-376), passive transfer of specific IgE to basophils was partially inhibited. This implies that M-272 recognizes a binding site on rCIgE(301-376) or sterically interferes with the rCIgE(301-376) high-affinity binding domains on human basophils.
Zotero 插件