Enerbäck L, Karlsson G, Pipkorn U
Ear, Nose, and Throat Department, University Hospital, Lund, Sweden.
Int Arch Allergy Appl Immunol. 1989;88(1-2):209-11. doi: 10.1159/000234788.
A redistribution of mast cells into the epithelium and towards the mucosal surface was previously observed during the allergy season in individuals allergic to birch pollen. We have therefore attempted to investigate in greater detail the role of mast cells in mucosal allergy by the study of the morphological and biochemical changes that occur in the nasal mucosa of allergic individuals during natural allergen exposure. An activation of the intraepithelial mast cells was indicated by the observation of ultrastructural signs of a secretory activity. We also found that the normal strong correlation between mast cell numbers and histamine content in the nasal mucosa was absent in specimens taken during allergen exposure, which was interpreted as a result of a release of histamine from the mast cells with the appearance of a transient, non-mast cell pool of tissue histamine. Furthermore, the histamine content of the nasal mucosa during the pollen season was strongly correlated to the severity of symptoms experienced by the patients. These observations provide additional evidence that mucosal mast cells have a pathogenetic role in continuous allergic airway disease.
先前在桦树花粉过敏个体的过敏季节期间，观察到肥大细胞重新分布到上皮组织并朝向粘膜表面。因此，我们试图通过研究过敏个体在自然过敏原暴露期间鼻黏膜中发生的形态学和生化变化，更详细地研究肥大细胞在粘膜过敏中的作用。上皮内肥大细胞的活化通过观察分泌活性的超微结构迹象得以表明。我们还发现，在过敏原暴露期间采集的标本中，鼻黏膜中肥大细胞数量与组胺含量之间正常的强相关性消失了，这被解释为肥大细胞释放组胺以及出现短暂的非肥大细胞组织组胺池的结果。此外，花粉季节期间鼻黏膜的组胺含量与患者经历的症状严重程度密切相关。这些观察结果提供了额外的证据，表明黏膜肥大细胞在持续性变应性气道疾病中具有致病作用。
