Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada AB T6G 2S2.
1] Department of Biological Sciences, University of Texas Brownsville, Brownsville, Texas 78520, USA [2] Department of Biomedical Sciences, University of Texas Brownsville, Brownsville, Texas 78520, USA.
Nat Commun. 2014 Apr 1;5:3549. doi: 10.1038/ncomms4549.
Vibrio cholerae is a Gram-negative bacterial pathogen that consists of over 200 serogroups with differing pathogenic potential. Only strains that express the virulence factors cholera toxin (CT) and toxin-coregulated pilus (TCP) are capable of pandemic spread of cholera diarrhoea. Regardless, all V. cholerae strains sequenced to date harbour genes for the type VI secretion system (T6SS) that translocates effectors into neighbouring eukaryotic and prokaryotic cells. Here we report that the effectors encoded within these conserved gene clusters differ widely among V. cholerae strains, and that immunity proteins encoded immediately downstream from the effector genes protect their host from neighbouring bacteria producing corresponding effectors. As a consequence, strains with matching effector-immunity gene sets can coexist, while strains with different sets compete against each other. Thus, the V. cholerae T6SS contributes to the competitive behaviour of this species.
霍乱弧菌是一种革兰氏阴性细菌病原体，由超过 200 个血清群组成，具有不同的致病潜力。只有表达霍乱毒素（CT）和毒素调节菌毛（TCP）这两种毒力因子的菌株才具有引发霍乱腹泻大流行的能力。然而，迄今为止所有测序的霍乱弧菌菌株都携带有类型 VI 分泌系统（T6SS）的基因，该系统可将效应蛋白转运至邻近的真核和原核细胞。在这里，我们报告称，这些保守基因簇中编码的效应蛋白在霍乱弧菌菌株之间存在广泛差异，并且位于效应基因下游编码的免疫蛋白可保护其宿主免受产生相应效应蛋白的邻近细菌的侵害。因此，具有匹配效应器-免疫基因集的菌株可以共存，而具有不同基因集的菌株则相互竞争。因此，霍乱弧菌 T6SS 有助于该物种的竞争行为。
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