von der Haar Tobias
School of Biosciences and Kent Fungal Group, University of Kent, Canterbury, CT2 7NJ, UK.
Comput Struct Biotechnol J. 2012 Feb 20;1:e201204002. doi: 10.5936/csbj.201204002. eCollection 2012.
Translation or protein synthesis consists of a complex system of chemical reactions, which ultimately result in decoding of the mRNA and the production of a protein. The complexity of this reaction system makes it difficult to quantitatively connect its input parameters (such as translation factor or ribosome concentrations, codon composition of the mRNA, or energy availability) to output parameters (such as protein synthesis rates or ribosome densities on mRNAs). Mathematical and computational models of translation have now been used for nearly five decades to investigate translation, and to shed light on the relationship between the different reactions in the system. This review gives an overview over the principal approaches used in the modelling efforts, and summarises some of the major findings that were made.
翻译或蛋白质合成由一个复杂的化学反应系统组成,最终导致mRNA的解码和蛋白质的产生。这个反应系统的复杂性使得难以将其输入参数(如翻译因子或核糖体浓度、mRNA的密码子组成或能量可用性)与输出参数(如蛋白质合成速率或mRNA上的核糖体密度)进行定量关联。翻译的数学和计算模型现已用于研究翻译近五十年,以阐明系统中不同反应之间的关系。本综述概述了建模工作中使用的主要方法,并总结了一些主要发现。